PKM and acute myeloid leukemia: Enhanced glucose-related metabolic pathways like glycolysis and pentose-phosphate pathway (PPP) and overexpression of some related key enzymes such as pyruvate kinase M2 (PKM2), lactate dehydrogenase A (LDHA) and glucose-6-phosphate dehydrogenase (G6PD), has been observed in AML cell lines and in human primary AML blasts that correlate with drug resistance and poorer prognosis [2].