COVID-19, history of diabetes, presumed obesity, age, APACHE II scores, use of corticosteroid, presence of nosocomial infection, SOFA scores, CRP values in the first 24 h, and mean values during ICU stay were each individually associated with the highest glucose level at admission, mean and highest glucose levels during ICU stay, mean glucose variability, and percentage of days with hyperglycemia, as shown in Table 2. This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.