Given differences between the groups regarding characteristics potentially influencing the causal relationship of COVID-19 and glucose abnormalities, the influence of COVID-19 on each of five of the continuous variables representing glucose abnormality at admission and during ICU stay were evaluated separately and adjusted for sex, history of diabetes, presumed obesity, age, APACHE II score, SOFA score, CRP level, presence of nosocomial infection, and use of corticosteroid. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.