In the multivariate explanatory models of mortality, the parameters of glycemic abnormalities: highest glucose level at admission, mean and highest glucose levels during ICU stay, glucose variability, and percentage of days with hyperglycemia, remained independent risk factors for mortality even after adjustment for variables related to mortality, including COVID-19, history of diabetes, nosocomial infection, age, APACHE II score, SOFA score, and CRP level. This evidence concerns the gene CRP and Hyperglycemia.