Novobiocin was found to hinder the interaction between the CH1 region of p300/CBP and HIF-1α C-TAD, which resulted in down-regulated expression of genes regulated by HIF-1α, especially CA9, resulting in an inhibitory effect on tumour cell proliferation, that eventually decreased mRNA expression of AKT1 and mTOR in A549 and MCF-7 cells60. Here, HIF1A is linked to neoplasm.