Therefore, we examined the percentage of CTLA-4 expressing CD4+CD25+Foxp3+cells (Treg cells) showed that the percentage of CTLA-4+Treg cells was significantly higher (non-sensitization; p = 0.040, sensitization; p = 0.044) in AD mice (Fig. 3b). The gene discussed is FOXP3; the disease is Alzheimer disease.