Dai et al. reported that ferroptosis induced by a high-iron diet or Gpx4 depletion activates the STING-dependent DNA sensor pathway, facilitating macrophage infiltration and progression of pancreatic cancer, and inhibition of STING pathway mitigates the ferroptosis and suppresses pancreatic tumorigenesis [59]. This evidence concerns the gene GPX4 and familial pancreatic carcinoma.