O-GlcNAcylation of Speckle-type POZ protein (SPOP) at Ser96 led to the translocation of SPOP from cytoplasm into nucleus, thus attenuating the ubiquitination of the oncoprotein neurite outgrowth inhibitor-B (Nogo-B) and promoting HCC progression [32]. Here, SPOP is linked to hepatocellular carcinoma.