Knockdown of ST6GAL1 significantly reduced the α2,6-sialylation level of CD63 on the surface of HCC-derived exosomes, leading to inactivated Akt/GSK-3β and JNK1/2 signaling pathways, which ultimately led to impaired HCC proliferation and metastasis [53]. The gene discussed is ST6GAL1; the disease is hepatocellular carcinoma.