OGT catalyzed O-GlcNAcylation of YTHDF2, an m6A binding protein, at Ser 263 to prevent ubiquitination-mediated degradation of YTHDF2 protein in HCC; subsequently, upregulated YTHDF2 promoted HCC proliferation via enhancing mRNA stability of m6A-modified MCM2 and MCM5 [30]. The gene discussed is YTHDF2; the disease is hepatocellular carcinoma.