EGFR and hepatocellular carcinoma: In addition, treatment of HCC with 2-fluoro-L-fucose (2FF), an analog of L-fucose, abolished core fucosylation of EGFR and integrin β1 on the cell surface via limiting GDP-fucose biosynthesis, leading to impaired pro-tumorigenic signalings and subsequent suppression of HCC cell proliferation and migration [55].