Mechanistic investigations showed that ST6GAL1-induced upregulation of α2,6-sialylation on melanoma cell adhesion molecule (MCAM) disrupted the interaction between MCAM and galectin-3, leading to impaired MCAM dimerization and consequent suppression of HCC metastasis both in vitro and in vivo [48]. Here, MCAM is linked to hepatocellular carcinoma.