Consistently, overexpressed FUT8 in HCV-infected HCC induced the expression of drug-resistant proteins such as P-glycoprotein (P-gp) and MRP1 to render 5-FU resistance of HCC cells; targeting of FUT8 or P-gp/MRP1 restored the sensitivity of HCC cells towards 5-FU treatment [66]. Here, FUT8 is linked to hepatocellular carcinoma.