In epirubicin- and mitoxantrone-resistant HCC cells, Kudo T et al. observed elevated core-fucosylated triantennary oligosaccharides compared to their parental cells, concomitant with altered mRNA expressions of glycosyltransferases synthesizing such as GnT-IVa, GnT-IVb and FUT8 [85]. The gene discussed is MGAT4A; the disease is hepatocellular carcinoma.