Overexpression of C1GALT1 in HCC stimulated hepatocyte growth factor (HGF) signaling by modulating the binding of MET with two O-glycans (Vicia villosa agglutinin and peanut agglutinin) and its dimerization, leading to elevated cell proliferation; conversely, blockade of MET using PHA665752 attenuated C1GALT1-driven HCC development [27]. The gene discussed is C1GALT1; the disease is hepatocellular carcinoma.