PRDM8 and Down syndrome: Aberrant DNAm in PRDM8 has also been observed previously in the premature aging disorders Dyskeratosis Congenita, Down syndrome, Hutchinson-Gilford Progeria syndrome, and Werner syndrome, but it is unknown if DM-CpGs in PRDM8 are involved in the disease processes or merely act as a biomarker for cellular aging30,31,57.