RHOA and colorectal carcinoma: Strikingly, CCG-1423 inhibitor promoted invasion as well as migration, and inhibited the phosphorylation of LIMK-1 and CFL-1 in HUNK control cells, but had no effects in HUNK KO cells (Supplementary Fig. S3D, E), suggesting that HUNK negatively regulates EMT via RhoA in CRC cells.