Moreover, PRMT1 inhibition increased the CD80 MFI in macrophages, indicating a relatively higher level of CD80 activation and cytotoxic T cells (GranB+CD8+) in CT26-cGAS-WT, but not the CT26-cGAS-KO cell-engrafted tumor (Fig. 5l, m). The gene discussed is DDX53; the disease is neoplasm.