Induction of type 2 diabetes mellitus with STZ directed statistically a significant (p < 0.001) increase in the Liver and Kidney profiles activity of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), Creatinine, GGT, Blood urea, Uric acid, Globulin and Fibrinogen in both type 2 diabetic stages e.g., stage 1(220–490) = day 7(diabetic) and stage 2(491–600) = week 9(diabetic) in the type 2 diabetic rats in comparison to normal ”stage 0 (< 200) = day 0 (control)” group as said the normal/control group. This evidence concerns the gene GPT and diabetes mellitus.