Our results, which had an estimated limit of detection of 20% variant allele frequency (VAF), demonstrated that (i) a subset of FLs harbored BCL2 single nucleotide variants (SNVs) at or above that frequency, (ii) the majority of these SNVs were amino acid-altering (nonsynonymous), and (iii) presence of these prevalent BCL2 SNVs was associated with earlier FL transformation and earlier death from lymphoma [38]. This evidence concerns the gene BCL2 and lymphoma.