In one study approximately 50% of male FraX patients had flat feet, 57% had excessive laxity of joints, and ten of the 150 male patients had scoliosis.7 In general, prepubertal boys with FraX have a general overgrowth and some FraX patients have increased height and stature.8 These bone alterations may be more prominent in females with absence of FMR1. While some of the morphological changes could be consistent with increased osteoblast activity, no data so far has been reported regarding bone mineral density in individuals with FraX. Here, FMR1 is linked to scoliosis.