A study that was done to identify the epigenetic molecular markers in plasma to detect CRC early has shown that tumor-specific methylation of adenomatous polyposis coli (APC), O‐6‐methylguanine‐DNA methyltransferase (MGMT), RASSF2A, and Wet inhibitory factor 1​​​​​​​ (Wif-1)genes could be valuable biomarkers. This evidence concerns the gene APC and colorectal carcinoma.