In animals, enhancing cortical SWA continuously for weeks, using optogenetic driving of excitatory cortical neurons reduces the amyloid burden and inhibits other AD markers in APP/PS1 mice [73], whereas chronic sleep deprivation in AD mice accelerates amyloid-β accumulation in the brain and worsens the cognitive deficits [74, 75]. Here, PSEN1 is linked to Alzheimer disease.