Cyclin-Dependent Kinase-Like 5 (CDKL5) encephalopathy is an X-linked disorder characterized by early-onset epilepsy with intractable seizures and severe psychomotor development delay, due to pathogenic variant (single nucleotide variant or large deletion) in CDKL5 gene located on Xp22. This evidence concerns the gene CDKL5 and Encephalopathy.