Glutamatergic excitatory neurotransmission is upregulated in CDKL5 encephalopathy, due to both alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor dysregulation and GluN2B NMDA-receptor (NMDA-R) subunit overexpression [6,19]. The gene discussed is CDKL5; the disease is Encephalopathy.