Tozuleristide, also known as BLZ-100 or “Tumor Paint,” is a biconjugate of a derivative of chlorotoxin, a small protein that is thought to selectively bind to targets such as calpactin and MMP-2 that are clustered in lipid rafts on the surface of glioma cells and CG.41 The gene discussed is MMP2; the disease is central nervous system cancer.