CALB1 and Alzheimer disease: We found that knockdown of neurotrophin receptor alike death domain protein (NRADD, Fig. 3A and B), in which the transmembrane and cytoplasmic regions are highly homologous to death receptor, such as p75 (Nadezhdin et al., 2019; Wang et al., 2003), effectively protected D28K+ cholinergic neurons from degeneration (Fig. 3C and D and Fig. S3) and completely eliminated the anxiety-like behaviors at the early stage of AD mice, without altering the performance in the Morris water maze tests (Fig. 4A–F).