Because dysbiosis and alterations in the intestinal microbiota are associated with the progress of IBD and AMPs play an important role in restricting the invasion of the microbes in gut (Muniz et al., 2012), we collected feces from the Vil-Cre;Otud4fl/fl and the Otud4fl/fl mice which were given 2.5% DSS in drinking water for 0 or 5 days, and analyzed the microbial composition in the feces by 16S rRNA sequencing assays. This evidence concerns the gene ADSL and inflammatory bowel disease.