Pathogenic scores of colitis which were evaluated by combining disease activity index (DAI) score and histopathological score also suggested similar pathology of the Lyz2-Cre;Otud4fl/fl and the Otud4fl/fl mice after DSS treatment (Fig. S1E), indicating that OTUD4 in myeloid cells plays a dispensable role in DSS-induced colitis. Here, OTUD4 is linked to colitis.