SRSF3 and cancer: Mouse embryos lacking SRSF3 do not form a blastocyst (Jumaa et al., 1999), and more importantly, we and others found that SRSF3 is tumorigenic acting as a proto-oncogene when overexpressed and is frequently upregulated in various types of cancer (Jia et al., 2010; He et al., 2004, 2011).