SYVN1 and infection: In contrast, infection with the ΔhtrA mutant resulted in activation of FOXO1 and SYVN1, but inhibited IL1RN and S100A6. After 6-h infection, both H. pylori wt and ΔhtrA mutant led to activation of ECSIT, FOXM1, MITF, MYBL2, MYC and TRAF2 genes (Fig. 7, Tables S9 and S10).