METTL3 and myocardial infarction: Compared with normal myocardial tissues, methyltransferase METTL3 is significantly up-regulated in myocardial tissues of patients with myocardial infarction, and promotes cardiomyocyte apoptosis under H/R by impairing autophagic flux, while demethylase ALKBH5 plays a opposite role in H/R mediated m6A modification of TFEB mRNA in cardiomyocytes (Song et al., 2019).