We hypothesized that β2-microglobulin is involved in SCI-related cognitive impairment in light of the recent reports linking β2-microglobulin to cognitive impairment, the correlation between systemic β2-microglobulin levels and cognitive decline, and the identification of β2-microglobulin as a potential pro-dementia factor associated with neurological damage. Here, HLA-G is linked to dementia.