It is generally believed that internal m6A modifications in mRNAs are the major substrates of FTO in many cell types studied so far, including acute myeloid leukemia (AML) cells and melanoma cells (Li et al., 2017; Su et al., 2018; Wei et al., 2018; Yang et al., 2019; Zhang et al., 2019). Here, FTO is linked to acute myeloid leukemia.