Although it is contradictory that mTOR plays negative roles in autophagy (Hosokawa et al., 2009), it shows the collaborate of mTOR and autophagy mediated by STYK1 at least in the cases of EGFR-TKIs resistance or pancreatic cancer with activating KRAS mutations and high basal autophagy (Rosenfeldt et al., 2013). This evidence concerns the gene KRAS and familial pancreatic carcinoma.