EGFR and lung carcinoma: To investigate the role of STYK1 in EGFR signaling, gene set enrichment analysis (GSEA) was generated using the Cancer Genome Atlas (TCGA) database of lung cancer, which is characterized by hyperexpression and/or gain-of-function mutations of EGFR (Tebbutt et al., 2013), to analyze differences in the genes that are enriched in patients with high and low levels of STYK1.