CLPP and neoplasm: Because ClpP inhibitors such as TR107 and ONC201 can both directly act on tumor cells and indirectly increase tumor kill by acting on normal cells in the tumor microenvironment (TME),38 the complete killing we observe when tumors are grown on OBSCs highlights a difference in functional killing patterns in vitro and on OBSCs that may be due to drug-tumor-OBSC interactions.