These include DIO2 (Type 2 Iodothyronine Deidinase, coverts thyroid prohormone [41]), EDN3 (Endothelin-3, mediates the release of vasodilators [42]), NPTX2 (Neuronal Pentraxin 2, which affect tumor progression [43]), KLF6 (Krueppel-like Factor 6, a tumor suppressor [44]), LPL (Lipoprotein Lipase, involved in lip metabolism [45]) and MAP1B (Microtubule Associated Protein [46]). The gene discussed is EDN3; the disease is neoplasm.