In contrast to NC-GBM tumors, lymphoid infiltration into C-GBM was reduced, and lymphocytes in C-GBM tumors bore a hyperactivated/exhausted phenotype characterized by increased expression of CD32, CD69, HLA-DR, CD27, and PD-1 on T cells that correlated with worse prognosis. The gene discussed is CD69; the disease is glioblastoma.