Lymphocytes and tissue-resident microglia were enriched in NC-GBM tumors and correlated with more favorable outcome, whereas antiinflammatory M2-like monocyte-derived macrophages (MDMs) bearing a distinct CD44+CD32+HLA-DR+ phenotype and exhausted PD-1+TIGIT+ T cells were enriched in C-GBM tumors. Here, PDCD1 is linked to glioblastoma.