While all STAT proteins assessed were phosphorylated following IFN-α stimulation in C-GBM and NC-GBM MDMs, NC-GBM MDMs favored an inflammatory ERK/p38/CREB signaling axis, while C-GBM MDMs favored 4E-BP1, S6, and NF-κB signaling, further supporting a role for the tumor environment in mediating differential myeloid signaling responses. This evidence concerns the gene IFNA1 and glioblastoma.