CXCR2 and lung cancer: Although mice lack CXCL8, other CXC chemokines, such as mouse CXCL5, the presumed orthologue of human CXCL6, signaling via the common receptor CXCR2 have been demonstrated as promoting lung cancer growth through neutrophil recruitment (75, 76), and mice with restored ability to produce CXCL8 are more susceptible to carcinogenesis through myeloid cell recruitment (77).