These findings support a role for the HERVH-driven, ectopically expressed calbindin isoform in protection from senescence of LUSC cancer cells in agreement with an involvement of the canonical calbindin in protection from senescence and apoptosis of nontransformed human and mouse cell types, where it is normally expressed (58, 59), and of ovarian cancer cells (60). This evidence concerns the gene CALB1 and cancer.