AR and breast cancer: Unlike previous preclinical attempts to explain the male predominance of BC through AR signaling, population-based data have not indicated a correlation between AR expression and sex in BC.39,40,41 Females with BC may therefore also experience the AR-mediated benefit of a 5-ARI; however, this benefit should be explored in future studies because there is currently no empirical evidence that supports the efficacy of 5-ARI administration in females with BC.