IGHE and asthma: Asthma is a long-term inflammatory condition affecting the airways which causes repeated occurrences of wheezing, difficulty breathing, tightness in the chest, and/or coughing mediated by IgE antibodies and Th2 lymphocytes [1], and allergic rhinitis refers to a condition characterized by sneezing, nasal itching, difficulty in breathing due to airflow obstruction, and clear nasal discharge, resulting from an IgE-mediated response to inhaled allergens that triggers inflammation of the nasal mucosa [2].