ANGPT2 and retinal disorder: The findings in this study, namely significant suppression of vitreous ANG2 protein and retina ANGPT2 mRNA (Fig. 2), were consistent with leakage scoring results from Schubert et al.35This study further confirms that, in high VEGF states in retinopathy, ANG2 levels increase, and, under suppressed VEGF concentrations, there is a corresponding decrease in ANG2 levels within the eye.