These medications include simvastatin (P = 9.76 × 10−19), which affects 17 of the 34 PVR genes and belongs to the most commonly prescribed drug class for hyperlipidemia, and cardiovascular agents, such as the ACE inhibitor enalapril (P = 3.70 × 10−17) and the beta blocker carvedilol (P = 5.65 × 10−17), both of which affect 11 of the 34 PVR genes and are two of the most prescribed drug classes for heart failure and hypertension. The gene discussed is ACE; the disease is heart failure.