Analysis of the PVR gene list with the Lynx Enrichment tool revealed top gene pathways such as “photodynamic therapy-induced AP-1 survival signaling,” “proteoglycans in cancer,” “AGE-RAGE signaling pathway in diabetic complication,” “interleukin-4 and 13 signaling,” “p53 signaling pathway,” “PI3K/Akt signaling pathway,” “EGFR tyrosine kinase inhibitor resistance,” “glucocorticoid receptor regulatory network,” “syndecan-2 mediated signaling events,” and “interleukin-18 signaling pathway” (Fig. 2). The gene discussed is IL18; the disease is cancer.