Moreover, the levels of blood glucose (P < 0.0001, T2DM versus TA) (Fig. 2C), IFN-γ (P < 0.0001, T2DM versus TA) (Fig. 3E), IL-1 (P < 0.0001, T2DM versus TA) (Fig. 3G), and IL-4 (P < 0.0001, T2DM versus TA) (Fig. 3F) were further elevated compared to those in T2DM zebrafish, indicating the successful establishment of the TA model. Here, IFNG is linked to type 2 diabetes mellitus.