ACHE and Alzheimer disease: Compared with the control group, the zebrafish AD model showed significantly elevated levels of AChE (P < 0.0001, CG versus AD) (Fig. 3A), Aβ1-42 (P < 0.0001, CG versus AD) (Fig. 3B), p-Tau (P < 0.0001, CG versus AD) (Fig. 3C), and Tau (P < 0.0001, CG versus AD) (Fig. 3D), indicating the model was successful.