Diacerein, an inhibitor of IL-1β production (46), and an IL-1R antagonist effectively reduced the ZIKV-mediated C3 induction in a dose-dependent manner, thereby suggesting the involvement of IL-1β in the induction of C3 gene expression by ZIKV infection (Fig. 7C and D). This evidence concerns the gene IL1R1 and Zika virus infectious disease.