Myeloid differentiation factor 88 (MyD88) is an adaptor protein (AP) that is used by most TLRs and MyD88-deficent mice demonstrate defective T cell function and aggravated colitis (Takeuchi and Akira, 2010; Pandey et al., 2014; Wang et al., 2015b). This evidence concerns the gene MYD88 and colitis.