However, lower levels of pro-inflammatory cytokines in the colon tissues of the NLRP3-deficient mice suggested that decreased NLRP3 inflammasome activation is required for amelioration of acute and chronic intestinal inflammation (Bauer et al., 2010; Wang et al., 2018b; Mehto et al., 2019; Sanchez-Lopez et al., 2019). This evidence concerns the gene NLRP3 and inflammation.