TLR2 and inflammation: TLR2 shows constitutive expression in the gastrointestinal epithelium and the enteric neurons, and mononuclear cells in the lamina propria even could release soluble forms of the TLR2 ectodomain, especially in patients with enteric inflammation (Aliprantis et al., 1999; Candia et al., 2012; Burgueño et al., 2016).