DnaJ-like heat shock protein 40 (HLJ1) is kind of tumor suppressor, and the expression of HLJ1 was proved to be transcriptionally increased by curcumin HLJ1 via an activator protein (AP-1) site in HLJ1 enhancer, particularly, JunD, as a kind of AP-1 components, was obviously increased. This evidence concerns the gene FOS and neoplasm.