Ang II-mediated cardiomyocyte growth could be suppressed by curcumin via inhibiting lipoprotein (ox-LDL) receptor-1 (LOX-1) and Ang II type 1 receptor (AT1R) expression and restoring the heightened condition of intracellular redox [144, 145], as well as down-regulating the level of SIRT1 after myocardial infarction (MI). The gene discussed is AGTR1; the disease is myocardial infarction.