Curcumin could inhibit the formation of tumor spheres by restricting the JAK2/STAT3 signal pathway [39] and suppress NSCLC cell migration by reducing the expression of AP-1 protein and suppressing the epithelial-mesenchymal transition (EMT) course, which are mediated by TLR4/MyD88-EGFR pathway [40]. The gene discussed is JUND; the disease is neoplasm.