One of the most undebatable and consistently reproduced experimental finding indicates that down regulation of GH signaling in animal models, such as in the caenorhabditis elegans[53] dwarf mice models[54-56],and models of IGF-1 deficiency[56-59] leads to remarkably long-lived species, both in mean and maximum lifespan, exhibiting multiple characteristics that suggest delayed aging (Table 1). The gene discussed is GH1; the disease is hyperinsulinemic hypoglycemia, familial, 4.