Piperine ameliorated cognitive impairments and enhanced memory function and movement performance; restored hippocampal neurotransmission (norepinephrine, DA, serotonin, GABA, and glutamate); attenuated increased levels of MDA activity, NO, IL-1β, IL-6, and TNF-α; and upregulated anti-inflammatory cytokines IL-14 and IL-10. This evidence concerns the gene TNF and Cognitive impairment.