In a model of amyotrophic lateral sclerosis (ALS), NF-κB was selectively inhibited in astrocytes and microglia respectively, and the researchers found that only restraining NF-κB signaling in microglia rescued motor neuron death by impairing proinflammatory microglial activation [123]. Here, NFKB1 is linked to amyotrophic lateral sclerosis.