KLK3 and pachyonychia congenita: Less likelihood for PC (aOR = 0.59, 95% CI: 0.35-0.99; aOR = 0.46, 95% CI: 0.27-0.77) or advanced PC (aOR = 0.49, 95% CI: 0.26-0.89; aOR = 0.33, 95% CI = 0.17-0.62) in men with urinary melatonin-sulfate level or melatonin-sulfate/cortisol ratio above the median; men with both low MT/C ratios and PSA level >10 ng/ml at 8.82-fold greater likelihood of PC and 32.06-fold greater likelihood of advanced PC; low MT/C ratio and PSA level > 10ng/ml showed greatest potential in detecting both PC and advanced PC