The first were tightly regulated, through MELK, BRCA2, KIF14, BUB1, and TOP2A, by five TFs (NFE2L3, RUNX1, RUNX2, BHLHE40, and the aging cancer-specific SOX11), two LncRNAs (ST7OT1 and CDKN2BAS), and four miRNAs (miR-21-5p, miR-363-3p, miR-873-5p, and miR-138-1-3p). The gene discussed is RUNX1; the disease is cancer.