AR and cancer: To overcome the major side effect of steroid imbalance,abiraterone is now prescribed with corticosteroids like prednisone.In addition, abiraterone can be metabolized by HSD3B1 and 5α-reductaseinto 3-keto-5α-abiraterone that is capable of activating androgenreceptor (AR), leading to the proliferation of cancer cells, underminingthe therapeutic effects of abiraterone.