Table 4 shows the association of Hs-CRP with cognitive impairment. We found that, during a median of 5.79 years follow-up, compared with the lowest quartile, participants in the highest quartile showed a 1.0814-fold (95% CI 1.0020–1.1671) higher risk of cognitive impairment. The results were similar in the sensitivity analyses, which showed a 1.0954-fold (95% CI 1.0013–1.1984; Table S4) and a 1.1379-fold (95% CI 1.0141–1.2770; Table S5) higher risk, respectively. The gene discussed is CRP; the disease is Cognitive impairment.