PIEZO1 and ischemia: Wang et al. found that the content of Piezo1 increased both in vivo (in rat cerebral cortex after the ischemia/reperfusion in the intraluminal middle cerebral artery occlusion model) and in vitro (in an oxygen-glucose deprivation/reoxygenation injury cell model) accompanied by decreasing in-cell viability and increasing in-cell apoptosis; on the contrary, these biological effects were reversed when the Piezo1 was inhibited [33].