In the evaluation of affective temperaments among the adult CF population (n = 55; age = 34.3 ± 10.9 years; F = 70.9%), the majority of whom were receiving CFTR modulation therapy (n = 40; 72.7%), we recorded n = 34 (61.8 %) cases of a current or lifetime psychiatric diagnosis, observed mainly in the female population (n = 27/39; 69.2%), with the most frequent diagnoses being anxiety disorder (n = 27) followed by cyclothymic disorder (n = 6). This evidence concerns the gene CFTR and cystic fibrosis.