Logistic regression analysis was performed by taking hypertension, total Fazekas score, and MIF level as independent variables, and whether cognitive impairment was combined as a dependent variable, and the results showed that the total Fazekas score (OR = 1.422, 95% CI = 1.023~1.976, p = 0.036) and serum MIF level (OR = 1.007, 95% CI = 1.000~1.014, p = 0.038) were risk factors for whether CSVD patients were combined with CI. Here, MIF is linked to Cognitive impairment.