The results showed an enrichment of CpG islands in the promoter regions of stress related genes and were significantly different between MDD-suicidal ideation and the healthy controls: BNDF (p = 0.039), FKBP5 (p = 0.035), CRHBP (p = 0.039) and NR3C1 (p = 0.025), but not CRHR1 (p = 0.37); between MDD-non-suicidal ideation and the healthy controls, significant differences were noted in: BNDF (p = 0.31), FKBP5 (p = 0.13), CRHBP (p = 0.72), CRHR1 (p = 0.96), and NR3C1 (p = 0.15), and this is associated with the decreased expression of BNDF, FKBPF5 (variants 1,2 y 3) NR3C1 genes in these patients. This evidence concerns the gene CRHBP and major depressive disorder.