NR3C1 and major depressive disorder: On the other hand, the NR3C1 expresses the cortisol receptor and mediates glucocorticoid actions, and it also functions as a hormone-dependent transcription factor that regulates the expression of glucocorticoid-responsive genes [35], which is hypermethylated in people with suicide ideation and depression [20], as well as the CRHBP gene, which codifies the corticotrophin-releasing factor-binding protein, regulates HPA axis function and stimulates synthesis and secretion of proopiomelanocortin derived peptides [36].