CCR2 and glioblastoma: For instance, Chen et al. demonstrated that CCR2+ inflammatory monocytes are rapidly recruited into a GBM orthotopic mouse model and they are highly motile cells to reach different zones, but they also could rapidly change to a stationary CX3CR1hiCCR2lo and CX3CR1hiCCR2– TAM profile in perivascular areas adjacent to endothelial cells and pericytes [73].