Moreover, multiple inflammatory cytokines, such as IL-1β, TNF-α, and IL-6 were significantly increased in the serum of patients with migraine attacks, showing that migraine is accompanied by systemic inflammation [41,58,59,60], which might be related to the enhanced BBB permeability in TNC induction following repeated dural stimulation [12]. The gene discussed is IL1B; the disease is migraine disorder.