TRIM22 and osteosarcoma: In addition, the relationship between BNIP3 expression and OS metastasis-related gene expression can be seen in Figure 8D. BNIP3 was positively correlated with genes that promote osteosarcoma metastasis, such as MYC, NELL1, SAR1A, and PLOD2, and negatively correlated with genes that inhibit osteosarcoma metastasis, such as TNFAIP8L1 and TRIM22, which suggested that a certain association exists between BNIP3 expression and OS metastasis.